Serine Protease Activation Essential for Endothelial–Mesenchymal Transition in Vascular Calcification | Zendy

Jiayi Yao | Zendy; Pierre Guihard | Zendy; Ana M. BlázquezMedela | Zendy; Yina Guo | Zendy; Jeremiah H. Moon | Zendy; Medet Jumabay | Zendy; Kristina I. Boström | Zendy; Yucheng Yao | Zendy

AI Assistant Blog Pricing

Home ZAIA Blog

Open Access

Serine Protease Activation Essential for Endothelial–Mesenchymal Transition in Vascular Calcification

Author(s) -

Jiayi Yao,

Pierre Guihard,

Ana M. BlázquezMedela,

Yina Guo,

Jeremiah H. Moon,

Medet Jumabay,

Kristina I. Boström,

Yucheng Yao

Publication year - 2015

Publication title -

circulation research

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 4.899

H-Index - 336

eISSN - 1524-4571

pISSN - 0009-7330

DOI - 10.1161/circresaha.115.306751

Subject(s) - proteases , endothelial stem cell , microbiology and biotechnology , biology , calcification , serine , mesenchymal stem cell , serine protease , endothelium , chemistry , biochemistry , protease , medicine , endocrinology , in vitro , enzyme , phosphorylation

Endothelial cells have the ability to undergo endothelial-mesenchymal transitions (EndMTs), by which they acquire a mesenchymal phenotype and stem cell-like characteristics. We previously found that EndMTs occurred in the endothelium deficient in matrix γ-carboxyglutamic acid protein enabling endothelial cells to contribute cells to vascular calcification. However, the mechanism responsible for initiating EndMTs is not fully understood.

The content you want is available to Zendy users.

Already have an account? Click here to sign in.

Having issues? You can contact us here

Accelerating Research