Open AccessThymidine Phosphorylase Participates in Platelet Signaling and Promotes Thrombosis
Author(s) -
Wei Li,
Alba Gigante,
Marı́a-Jesús Pérez-Pérez,
Hong Yue,
Michio Hirano,
Thomas M. McIntyre,
Roy L. Silverstein
Publication year - 2014
Publication title -
circulation research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 4.899
H-Index - 336
eISSN - 1524-4571
pISSN - 0009-7330
DOI - 10.1161/circresaha.115.304591
Subject(s) - lyn , platelet , platelet activation , cancer research , tyrosine kinase , chemistry , pharmacology , medicine , signal transduction , biochemistry
Platelets contain abundant thymidine phosphorylase (TYMP), which is highly expressed in diseases with high risk of thrombosis, such as atherosclerosis and type II diabetes mellitus.
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