Pi3kcb Links Hippo-YAP and PI3K-AKT Signaling Pathways to Promote Cardiomyocyte Proliferation and Survival | Zendy

Zhiqiang Lin | Zendy; Pingzhu Zhou | Zendy; Alexander von Gise | Zendy; Fei Gu | Zendy; Qing Ma | Zendy; Jinghai Chen | Zendy; Hai-dong Guo | Zendy; Pim R.R. van Gorp | Zendy; DaZhi Wang | Zendy; William T. Pu | Zendy

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Pi3kcb Links Hippo-YAP and PI3K-AKT Signaling Pathways to Promote Cardiomyocyte Proliferation and Survival

Author(s) -

Zhiqiang Lin,

Pingzhu Zhou,

Alexander von Gise,

Fei Gu,

Qing Ma,

Jinghai Chen,

Hai-dong Guo,

Pim R.R. van Gorp,

DaZhi Wang,

William T. Pu

Publication year - 2014

Publication title -

circulation research

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 4.899

H-Index - 336

eISSN - 1524-4571

pISSN - 0009-7330

DOI - 10.1161/circresaha.115.304457

Subject(s) - biology , hippo signaling pathway , enhancer , microbiology and biotechnology , protein kinase b , effector , gene knockdown , pi3k/akt/mtor pathway , chromatin immunoprecipitation , signal transduction , transcription factor , cancer research , gene expression , gene , promoter , genetics

Yes-associated protein (YAP), the nuclear effector of Hippo signaling, regulates cellular growth and survival in multiple organs, including the heart, by interacting with TEA (transcriptional enhancer activator)-domain sequence-specific DNA-binding proteins. Recent studies showed that YAP stimulates cardiomyocyte proliferation and survival. However, the direct transcriptional targets through which YAP exerts its effects are poorly defined.

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