Open AccessTransgenic Expression of Dominant-Active IDOL in Liver Causes Diet-Induced Hypercholesterolemia and Atherosclerosis in Mice
Author(s) -
Anna C. Calkin,
Stephen D. Lee,
Jason Kim,
Caroline M.W. van Stijn,
Xiaohui Wu,
Aldons J. Lusis,
Cynthia Hong,
Rajendra I. Tangirala,
Peter Tontonoz
Publication year - 2014
Publication title -
circulation research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 4.899
H-Index - 336
eISSN - 1524-4571
pISSN - 0009-7330
DOI - 10.1161/circresaha.115.304440
Subject(s) - ldl receptor , endocrinology , medicine , apolipoprotein b , lipoprotein , genetically modified mouse , receptor , biology , cholesterol , proinflammatory cytokine , transgene , liver x receptor , low density lipoprotein , inflammation , gene , biochemistry , nuclear receptor , transcription factor
The E3 ubiquitin ligase inducible degrader of the low-density lipoprotein receptor (IDOL) triggers lysosomal degradation of the low-density lipoprotein receptor. The tissue-specific effects of the IDOL pathway on plasma cholesterol and atherosclerosis have not been examined.
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