Open AccessA Large Permissive Regulatory Domain Exclusively Controls Tbx3 Expression in the Cardiac Conduction System
Author(s) -
Jan Hendrik van Weerd,
Ileana Badi,
Malou van den Boogaard,
Sonia Stefanovic,
Harmen J.G. van de Werken,
Melisa Gómez-Velázquez,
Claudio Badía-Careaga,
Miguel Manzanares,
Wouter de Laat,
Phil Barnett,
Vincent M. Christoffels
Publication year - 2014
Publication title -
circulation research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 4.899
H-Index - 336
eISSN - 1524-4571
pISSN - 0009-7330
DOI - 10.1161/circresaha.115.303591
Subject(s) - ctcf , enhancer , transcription factor , locus (genetics) , biology , gene , genetics , microbiology and biotechnology , locus control region , insulator (electricity) , regulation of gene expression , promoter , gene expression , electrical engineering , engineering
The evolutionary conserved Tbx3/Tbx5 gene cluster encodes T-box transcription factors that play crucial roles in the development and homeostasis of the cardiac conduction system in human and mouse. Both genes are expressed in overlapping patterns and function in strictly tissue-specific and dose-dependent manners, yet, their regulation is poorly understood.
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