The Hippo Pathway Is Activated and Is a Causal Mechanism for Adipogenesis in Arrhythmogenic Cardiomyopathy | Zendy

Suet Nee Chen | Zendy; Priyatansh Gurha | Zendy; Raffaella Lombardi | Zendy; Alessandra Ruggiero | Zendy; James T. Willerson | Zendy; Ali J. Marian | Zendy

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The Hippo Pathway Is Activated and Is a Causal Mechanism for Adipogenesis in Arrhythmogenic Cardiomyopathy

Author(s) -

Suet Nee Chen,

Priyatansh Gurha,

Raffaella Lombardi,

Alessandra Ruggiero,

James T. Willerson,

Ali J. Marian

Publication year - 2013

Publication title -

circulation research

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 4.899

H-Index - 336

eISSN - 1524-4571

pISSN - 0009-7330

DOI - 10.1161/circresaha.114.302810

Subject(s) - hippo signaling pathway , microbiology and biotechnology , biology , transcription factor , wnt signaling pathway , gene knockdown , kinase , plakoglobin , beta catenin , signal transduction , catenin , biochemistry , gene

Mutations in the intercalated disc proteins, such as plakophilin 2 (PKP2), cause arrhythmogenic cardiomyopathy (AC). AC is characterized by the replacement of cardiac myocytes by fibro-adipocytes, cardiac dysfunction, arrhythmias, and sudden death.

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