Open AccessActivation of NADPH Oxidase 4 in the Endoplasmic Reticulum Promotes Cardiomyocyte Autophagy and Survival During Energy Stress Through the Protein Kinase RNA-Activated-Like Endoplasmic Reticulum Kinase/Eukaryotic Initiation Factor 2α/Activating Transcription Factor 4 Pathway
Author(s) -
Sebastiano Sciarretta,
Peiyong Zhai,
Dan Shao,
Daniela Zablocki,
Narayani Nagarajan,
Lance S. Terada,
Massimo Volpe,
Junichi Sadoshima
Publication year - 2013
Publication title -
circulation research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 4.899
H-Index - 336
eISSN - 1524-4571
pISSN - 0009-7330
DOI - 10.1161/circresaha.113.301787
Subject(s) - endoplasmic reticulum , microbiology and biotechnology , autophagy , ask1 , kinase , protein kinase a , protein kinase r , chemistry , biology , biochemistry , mitogen activated protein kinase kinase , apoptosis
Autophagy is an essential survival mechanism during energy stress in the heart. Oxidative stress is activated by energy stress, but its role in mediating autophagy is poorly understood. NADPH oxidase (Nox) 4 is an enzyme that generates reactive oxygen species (ROS) at intracellular membranes. Whether Nox4 acts as a sensor of energy stress to mediate activation of autophagy is unknown.
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