Open AccessAbnormal Propagation of Calcium Waves and Ultrastructural Remodeling in Recessive Catecholaminergic Polymorphic Ventricular Tachycardia
Author(s) -
Nian Liu,
Marco Denegri,
Wen Dun,
Simona Boncompagni,
Francesco Lodola,
Feliciano Protasi,
Carlo Napolitano,
Penelope A. Boyden,
Silvia G. Priori
Publication year - 2013
Publication title -
circulation research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 4.899
H-Index - 336
eISSN - 1524-4571
pISSN - 0009-7330
DOI - 10.1161/circresaha.113.301783
Subject(s) - catecholaminergic polymorphic ventricular tachycardia , calsequestrin , ryanodine receptor 2 , medicine , ryanodine receptor , endocrinology , myocyte , catecholaminergic , endoplasmic reticulum , biology , afterdepolarization , calcium , electrophysiology , microbiology and biotechnology , catecholamine , repolarization
The recessive form of catecholaminergic polymorphic ventricular tachycardia is caused by mutations in the cardiac calsequestrin-2 gene; this variant of catecholaminergic polymorphic ventricular tachycardia is less well characterized than the autosomal-dominant form caused by mutations in the ryanodine receptor-2 gene.
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