Transplantation of Mesenchymal Cells Rejuvenated by the Overexpression of Telomerase and Myocardin Promotes Revascularization and Tissue Repair in a Murine Model of Hindlimb Ischemia | Zendy

Rosalinda Madonna | Zendy; Doris A. Taylor | Zendy; YongJian Geng | Zendy; Raffaele De Caterina | Zendy; Harnath Shelat | Zendy; Emerson C. Perin | Zendy; James T. Willerson | Zendy

Open Access

Transplantation of Mesenchymal Cells Rejuvenated by the Overexpression of Telomerase and Myocardin Promotes Revascularization and Tissue Repair in a Murine Model of Hindlimb Ischemia

Author(s) -

Rosalinda Madonna,

Doris A. Taylor,

YongJian Geng,

Raffaele De Caterina,

Harnath Shelat,

Emerson C. Perin,

James T. Willerson

Publication year - 2013

Publication title -

circulation research

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 4.899

H-Index - 336

eISSN - 1524-4571

pISSN - 0009-7330

DOI - 10.1161/circresaha.113.301690

Subject(s) - mesenchymal stem cell , myocardin , stem cell , biology , cancer research , microbiology and biotechnology , adipose tissue , transplantation , telomerase , pathology , medicine , endocrinology , gene expression , serum response factor , biochemistry , gene

The number and function of stem cells decline with aging, reducing the ability of stem cells to contribute to endogenous repair processes. The repair capacity of stem cells in older individuals may be improved by genetically reprogramming the stem cells to exhibit delayed senescence and enhanced regenerative properties.

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