Synaptojanin-2 Binding Protein Stabilizes the Notch Ligands DLL1 and DLL4 and Inhibits Sprouting Angiogenesis | Zendy

Mohamed Adam | Zendy; Caroline Berger | Zendy; Anja Feldner | Zendy; W.-J. Yang | Zendy; Joycelyn WüstehubeLausch | Zendy; Stefanie E. Herberich | Zendy; Marcel Pinder | Zendy; Sabine Gesierich | Zendy; Hans-Peter Hammes | Zendy; Hellmut G. Augustin | Zendy; Andreas Fischer | Zendy

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Synaptojanin-2 Binding Protein Stabilizes the Notch Ligands DLL1 and DLL4 and Inhibits Sprouting Angiogenesis

Author(s) -

Mohamed Adam,

Caroline Berger,

Anja Feldner,

W.-J. Yang,

Joycelyn WüstehubeLausch,

Stefanie E. Herberich,

Marcel Pinder,

Sabine Gesierich,

Hans-Peter Hammes,

Hellmut G. Augustin,

Andreas Fischer

Publication year - 2013

Publication title -

circulation research

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 4.899

H-Index - 336

eISSN - 1524-4571

pISSN - 0009-7330

DOI - 10.1161/circresaha.113.301686

Subject(s) - notch signaling pathway , microbiology and biotechnology , angiogenesis , sprouting angiogenesis , notch proteins , angiopoietin , notch 1 , vascular endothelial growth factor , vascular endothelial growth factor a , biology , chemistry , signal transduction , cancer research , neovascularization , vegf receptors

The formation of novel blood vessels is initiated by vascular endothelial growth factor. Subsequently, DLL4-Notch signaling controls the selection of tip cells, which guide new sprouts, and trailing stalk cells. Notch signaling in stalk cells is induced by DLL4 on the tip cells. Moreover, DLL4 and DLL1 are expressed in the stalk cell plexus to maintain Notch signaling. Notch loss-of-function causes formation of a hyperdense vascular network with disturbed blood flow.

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