Open AccessA Novel Mouse Model of Atherosclerotic Plaque Instability for Drug Testing and Mechanistic/Therapeutic Discoveries Using Gene and MicroRNA Expression Profiling
Author(s) -
YungChih Chen,
Anh Bui,
Jeannine Diesch,
Richard Manasseh,
Christian Hausding,
Jennifer Rivera,
Izhak Haviv,
Alex Agrotis,
Nay Htun,
Jeremy B. M. Jowett,
Christoph E. Hagemeyer,
Ross D. Hannan,
Alex Bobik,
Karlheinz Peter
Publication year - 2013
Publication title -
circulation research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 4.899
H-Index - 336
eISSN - 1524-4571
pISSN - 0009-7330
DOI - 10.1161/circresaha.113.301562
Subject(s) - microrna , gene expression profiling , computational biology , drug , profiling (computer programming) , biology , gene expression , gene , bioinformatics , cancer research , pharmacology , genetics , computer science , operating system
The high morbidity/mortality of atherosclerosis is typically precipitated by plaque rupture and consequent thrombosis. However, research on underlying mechanisms and therapeutic approaches is limited by the lack of animal models that reproduce plaque instability observed in humans.
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