ATP-Binding Cassette B10 Regulates Early Steps of Heme Synthesis | Zendy

Marina Bayeva | Zendy; Arineh Khechaduri | Zendy; Rongxue Wu | Zendy; Michael A. Burke | Zendy; J. Andrew Wasserstrom | Zendy; Neha Singh | Zendy; Marc Liesa | Zendy; Orian S. Shirihai | Zendy; Nathaniel B. Langer | Zendy; Barry H. Paw | Zendy; Hossein Ardehali | Zendy

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ATP-Binding Cassette B10 Regulates Early Steps of Heme Synthesis

Author(s) -

Marina Bayeva,

Arineh Khechaduri,

Rongxue Wu,

Michael A. Burke,

J. Andrew Wasserstrom,

Neha Singh,

Marc Liesa,

Orian S. Shirihai,

Nathaniel B. Langer,

Barry H. Paw,

Hossein Ardehali

Publication year - 2013

Publication title -

circulation research

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 4.899

H-Index - 336

eISSN - 1524-4571

pISSN - 0009-7330

DOI - 10.1161/circresaha.113.301552

Subject(s) - heme , gene knockdown , mitochondrion , downregulation and upregulation , microbiology and biotechnology , biology , biochemistry , apoptosis , enzyme , gene

Heme plays a critical role in gas exchange, mitochondrial energy production, and antioxidant defense in cardiovascular system. The mitochondrial transporter ATP-binding cassette (ABC) B10 has been suggested to export heme out of the mitochondria and is required for normal hemoglobinization of erythropoietic cells and protection against ischemia-reperfusion injury in the heart; however, its primary function has not been established.

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