Open AccessEndothelial Cell–Dependent Regulation of Arteriogenesis
Author(s) -
Filipa Moraes,
Julie M. D. Paye,
Feilim Mac Gabhann,
Zhen W. Zhuang,
Jiasheng Zhang,
Anthony A. Lanahan,
Michael Simons
Publication year - 2013
Publication title -
circulation research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 4.899
H-Index - 336
eISSN - 1524-4571
pISSN - 0009-7330
DOI - 10.1161/circresaha.113.301340
Subject(s) - arteriogenesis , microbiology and biotechnology , endothelial stem cell , endothelium , cell , chemistry , biology , medicine , angiogenesis , biochemistry , in vitro
Arteriogenesis is the process of formation of arterial conduits. Its promotion is an attractive therapeutic strategy in occlusive atherosclerotic diseases. Despite the functional and clinical importance of arteriogenesis, the biology of the process is poorly understood. Synectin, a gene previously implicated in the regulation of vascular endothelial cell growth factor signaling, offers a unique opportunity to determine relative contributions of various cell types to arteriogenesis.
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