Open AccessMicroRNA-663 Regulates Human Vascular Smooth Muscle Cell Phenotypic Switch and Vascular Neointimal Formation
Author(s) -
Pan Li,
Ni Zhu,
Bin Yi,
Nadan Wang,
Ming Chen,
Xiaohua You,
Xianxian Zhao,
Charalambos Solomides,
Yongwen Qin,
Jianxin Sun
Publication year - 2013
Publication title -
circulation research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 4.899
H-Index - 336
eISSN - 1524-4571
pISSN - 0009-7330
DOI - 10.1161/circresaha.113.301306
Subject(s) - junb , vascular smooth muscle , neointima , calponin , myosin , microbiology and biotechnology , myocardin , myosin light chain kinase , biology , cell growth , phenotypic switching , growth factor , vascular remodelling in the embryo , neointimal hyperplasia , myosin light chain phosphatase , transcription factor , endocrinology , medicine , serum response factor , restenosis , actin , biochemistry , receptor , gene , smooth muscle , stent
Abnormal phenotypic switch of vascular smooth muscle cell (VSMC) is a hallmark of vascular disorders such as atherosclerosis and restenosis after angioplasty. MicroRNAs (miRNAs) have emerged as important regulators for VSMC function, and we recently identified miR-663 as critical for controlling human aortic smooth muscle cell proliferation.
Accelerating Research
Robert Robinson Avenue,
Oxford Science Park, Oxford
OX4 4GP, United Kingdom
Address
John Eccles HouseRobert Robinson Avenue,
Oxford Science Park, Oxford
OX4 4GP, United Kingdom