Open AccessRegulation of Cardiac Hypertrophic Signaling by Prolyl Isomerase Pin1
Author(s) -
Haruhiro Toko,
Mathias H. Konstandin,
Shirin Doroudgar,
Lucia Ormachea,
Eri Joyo,
Anya Joyo,
Shabana Din,
Natalie Gude,
Brett Collins,
Mirko Völkers,
Donna J. Thuerauf,
Christopher C. Glembotski,
Chun-Hau Chen,
Kun Ping Lu,
Oliver J. Müller,
Takafumi Uchida,
Mark A. Sussman
Publication year - 2013
Publication title -
circulation research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 4.899
H-Index - 336
eISSN - 1524-4571
pISSN - 0009-7330
DOI - 10.1161/circresaha.113.301084
Subject(s) - pin1 , prolyl isomerase , isomerase , peptidylprolyl isomerase , biology , medicine , microbiology and biotechnology , chemistry , biochemistry , enzyme
Cardiac hypertrophy results from the complex interplay of differentially regulated cascades based on the phosphorylation status of involved signaling molecules. Although numerous critical regulatory kinases and phosphatases have been identified in the myocardium, the intracellular mechanism for temporal regulation of signaling duration and intensity remains obscure. In the nonmyocyte context, control of folding, activity, and stability of proteins is mediated by the prolyl isomerase Pin1, but the role of Pin1 in the heart is unknown.
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