Open AccessLRP1-Dependent Endocytic Mechanism Governs the Signaling Output of the Bmp System in Endothelial Cells and in Angiogenesis
Author(s) -
Xinchun Pi,
Christopher E. Schmitt,
Liang Xie,
Andrea L. Portbury,
Yaxu Wu,
Pamela Lockyer,
Laura A. Dyer,
Martin Moser,
Guojun Bu,
Edward J. Flynn,
Suk-Won Jin,
Cam Patterson
Publication year - 2012
Publication title -
circulation research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 4.899
H-Index - 336
eISSN - 1524-4571
pISSN - 0009-7330
DOI - 10.1161/circresaha.112.274597
Subject(s) - lrp1 , endocytic cycle , microbiology and biotechnology , endocytosis , biology , signal transduction , bmpr2 , bone morphogenetic protein , ldl receptor , cell signaling , angiogenesis , receptor , cancer research , biochemistry , lipoprotein , gene , cholesterol
Among the extracellular modulators of Bmp (bone morphogenetic protein) signaling, Bmper (Bmp endothelial cell precursor-derived regulator) both enhances and inhibits Bmp signaling. Recently we found that Bmper modulates Bmp4 activity via a concentration-dependent, endocytic trap-and-sink mechanism.
Accelerating Research
Robert Robinson Avenue,
Oxford Science Park, Oxford
OX4 4GP, United Kingdom
Address
John Eccles HouseRobert Robinson Avenue,
Oxford Science Park, Oxford
OX4 4GP, United Kingdom