F-Box and Leucine-Rich Repeat Protein 22 Is a Cardiac-Enriched F-Box Protein That Regulates Sarcomeric Protein Turnover and Is Essential for Maintenance of Contractile Function In Vivo | Zendy

Sebastian Spaich | Zendy; Rainer Will | Zendy; Steffen Just | Zendy; Saskia Spaich | Zendy; Christian Kühn | Zendy; Derk Frank | Zendy; Ina M. Berger | Zendy; Stefan Wiemann | Zendy; Bernhard Korn | Zendy; Manfred Koegl | Zendy; Johannes Backs | Zendy; Hugo A. Katus | Zendy; Eckhard Wolf | Zendy; Norbert Frey | Zendy

Open Access

F-Box and Leucine-Rich Repeat Protein 22 Is a Cardiac-Enriched F-Box Protein That Regulates Sarcomeric Protein Turnover and Is Essential for Maintenance of Contractile Function In Vivo

Author(s) -

Sebastian Spaich,

Rainer Will,

Steffen Just,

Saskia Spaich,

Christian Kühn,

Derk Frank,

Ina M. Berger,

Stefan Wiemann,

Bernhard Korn,

Manfred Koegl,

Johannes Backs,

Hugo A. Katus,

Eckhard Wolf,

Norbert Frey

Publication year - 2012

Publication title -

circulation research

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 4.899

H-Index - 336

eISSN - 1524-4571

pISSN - 0009-7330

DOI - 10.1161/circresaha.112.271007

Subject(s) - skp1 , filamin , biology , protein degradation , actinin , ubiquitin , proteasome , f box protein , microbiology and biotechnology , ubiquitin ligase , gene knockdown , sarcomere , immunoprecipitation , myocyte , biochemistry , cell , gene , cytoskeleton

The emerging role of the ubiquitin-proteasome system in cardiomyocyte function and homeostasis implies the necessity of tight regulation of protein degradation. However, little is known about cardiac components of this machinery.

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