MicroRNA-Mediated In Vitro and In Vivo Direct Reprogramming of Cardiac Fibroblasts to Cardiomyocytes | Zendy

Tilanthi M. Jayawardena | Zendy; Bakytbek Egemnazarov | Zendy; Elizabeth Finch | Zendy; Lunan Zhang | Zendy; Jonathan Payne | Zendy; Kumar Pandya | Zendy; Zhiping Zhang | Zendy; Paul B. Rosenberg | Zendy; Maria Mirotsou | Zendy; Victor J. Dzau | Zendy

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MicroRNA-Mediated In Vitro and In Vivo Direct Reprogramming of Cardiac Fibroblasts to Cardiomyocytes

Author(s) -

Tilanthi M. Jayawardena,

Bakytbek Egemnazarov,

Elizabeth Finch,

Lunan Zhang,

Jonathan Payne,

Kumar Pandya,

Zhiping Zhang,

Paul B. Rosenberg,

Maria Mirotsou,

Victor J. Dzau

Publication year - 2012

Publication title -

circulation research

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 4.899

H-Index - 336

eISSN - 1524-4571

pISSN - 0009-7330

DOI - 10.1161/circresaha.112.269035

Subject(s) - reprogramming , microbiology and biotechnology , biology , microrna , regenerative medicine , transdifferentiation , in vivo , phenotype , cell type , transfection , in vitro , cell , cancer research , cell culture , stem cell , gene , genetics

Repopulation of the injured heart with new, functional cardiomyocytes remains a daunting challenge for cardiac regenerative medicine. An ideal therapeutic approach would involve an effective method at achieving direct conversion of injured areas to functional tissue in situ.

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