Nuclear miRNA Regulates the Mitochondrial Genome in the Heart
Author(s) -
Samarjit Das,
Marcella Ferlito,
Oliver A. Kent,
Karen Fox-Talbot,
Richard Wang,
Delong Liu,
Nalini Raghavachari,
Yanqin Yang,
Sarah J. Wheelan,
Elizabeth Murphy,
Charles Steenbergen
Publication year - 2012
Publication title -
circulation research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 4.899
H-Index - 336
eISSN - 1524-4571
pISSN - 0009-7330
DOI - 10.1161/circresaha.112.267732
Subject(s) - mitochondrion , biology , microbiology and biotechnology , microrna , myocyte , messenger rna , mitochondrial dna , cytoplasm , gene , genetics
Mitochondria are semiautonomous cellular organelles with their own genome, which not only supply energy but also participate in cell death pathways. MicroRNAs (miRNAs) are usually 19 to 25 nt long, noncoding RNAs, involved in posttranscriptional gene regulation by binding to the 3'-untranslated regions of target mRNA, which impact on diverse cellular processes.
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