Asymmetric Chromatid Segregation in Cardiac Progenitor Cells Is Enhanced by Pim-1 Kinase | Zendy

Balaji Sundararaman | Zendy; Daniele Avitabile | Zendy; Mathias H. Konstandin | Zendy; Christopher T. Cottage | Zendy; Natalie Gude | Zendy; Mark A. Sussman | Zendy

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Asymmetric Chromatid Segregation in Cardiac Progenitor Cells Is Enhanced by Pim-1 Kinase

Author(s) -

Balaji Sundararaman,

Daniele Avitabile,

Mathias H. Konstandin,

Christopher T. Cottage,

Natalie Gude,

Mark A. Sussman

Publication year - 2012

Publication title -

circulation research

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 4.899

H-Index - 336

eISSN - 1524-4571

pISSN - 0009-7330

DOI - 10.1161/circresaha.112.267716

Subject(s) - chromatid , sister chromatids , biology , asymmetric cell division , microbiology and biotechnology , mitosis , cell division , stem cell , bromodeoxyuridine , cytokinesis , chromosome segregation , genetics , cell , cell growth , chromosome , gene

Cardiac progenitor cells (CPCs) in the adult heart are used for cell-based treatment of myocardial damage, but factors determining stemness, self-renewal, and lineage commitment are poorly understood. Immortal DNA strands inherited through asymmetric chromatid segregation correlate with self-renewal of adult stem cells, but the capacity of CPCs for asymmetric segregation to retain immortal strands is unknown. Cardioprotective kinase Pim-1 increases asymmetric cell division in vivo, but the ability of Pim-1 to enhance asymmetric chromatid segregation is unknown.

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