Open AccessSmooth Muscle Cell–Specific Runx2 Deficiency Inhibits Vascular Calcification
Author(s) -
Yong Sun,
Chang Hyun Byon,
Kaiyu Yuan,
Jianfeng Chen,
Xia Mao,
Jack Heath,
Amjad Javed,
Kui Zhang,
Peter G. Anderson,
Yabing Chen
Publication year - 2012
Publication title -
circulation research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 4.899
H-Index - 336
eISSN - 1524-4571
pISSN - 0009-7330
DOI - 10.1161/circresaha.112.267237
Subject(s) - runx2 , vascular smooth muscle , calcification , osteoclast , biology , medicine , endocrinology , microbiology and biotechnology , receptor , osteoblast , in vitro , biochemistry , smooth muscle
Vascular calcification is a hallmark of atherosclerosis, a major cause of morbidity and mortality in the United States. We have previously reported that the osteogenic transcription factor Runx2 is an essential and sufficient regulator of calcification of vascular smooth muscle cells (VSMC) in vitro.
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