Open AccessGene Silencing of the Mitochondrial Adaptor p66 Shc Suppresses Vascular Hyperglycemic Memory in Diabetes
Author(s) -
Francesco Paneni,
Pavani Mocharla,
Alexander Akhmedov,
Sarah Costantino,
Elena Osto,
Massimo Volpe,
Thomas F. Lüscher,
Francesco Cosentino
Publication year - 2012
Publication title -
circulation research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 4.899
H-Index - 336
eISSN - 1524-4571
pISSN - 0009-7330
DOI - 10.1161/circresaha.112.266593
Subject(s) - downregulation and upregulation , gene silencing , glycation , mitochondrial ros , microbiology and biotechnology , medicine , biology , endocrinology , chemistry , reactive oxygen species , diabetes mellitus , biochemistry , gene
Hyperglycemic memory may explain why intensive glucose control has failed to improve cardiovascular outcomes in patients with diabetes. Indeed, hyperglycemia promotes vascular dysfunction even after glucose normalization. However, the molecular mechanisms of this phenomenon remain to be elucidated.
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