Open AccessNoise-Free Visualization of Microscopic Calcium Signaling by Pixel-Wise Fitting
Author(s) -
Xiao Yu Tian,
Lars Kaestner,
Peter Lipp
Publication year - 2012
Publication title -
circulation research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 4.899
H-Index - 336
eISSN - 1524-4571
pISSN - 0009-7330
DOI - 10.1161/circresaha.112.266403
Subject(s) - confocal , confocal microscopy , coupling (piping) , contraction (grammar) , biological system , biophysics , chemistry , computer science , physics , materials science , optics , biology , metallurgy , endocrinology
Our insights into physiological and pathophysiological cardiac excitation-contraction coupling has greatly benefited from significant advancement in optical technologies such as high-speed confocal microscopy. This has pushed pixel dwell times into the time domain of nanoseconds, resulting in low signal-to-noise ratios, which have limited data analysis and interpretation.
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