Open AccessElevated Ecto-5'-nucleotidase-Mediated Increased Renal Adenosine Signaling Via A2B Adenosine Receptor Contributes to Chronic Hypertension
Author(s) -
Weiru Zhang,
Yujin Zhang,
Wei Wang,
Yingbo Dai,
Ning Chen,
Renna Luo,
Kaiqi Sun,
Louise Glover,
Almut Grenz,
Hong Sun,
Lijian Tao,
Wenzheng Zhang,
Sean P. Colgan,
Michael R. Blackburn,
Holger K. Eltzschig,
Rodney E. Kellems,
Yang Xia
Publication year - 2013
Publication title -
circulation research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 4.899
H-Index - 336
eISSN - 1524-4571
pISSN - 0009-7330
DOI - 10.1161/circresaha.111.300166
Subject(s) - adenosine , adenosine receptor , 5' nucleotidase , purinergic signalling , medicine , endocrinology , nucleotidase , receptor , adenosine a3 receptor , signal transduction , adenosine a1 receptor , chemistry , pharmacology , microbiology and biotechnology , biology , agonist
Hypertension is the most prevalent life-threatening disease worldwide and is frequently associated with chronic kidney disease (CKD). However, the molecular basis underlying hypertensive CKD is not fully understood.
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