Open AccessHyperamylinemia Contributes to Cardiac Dysfunction in Obesity and Diabetes
Author(s) -
Sanda Despa,
Kenneth B. Margulies,
Le Chen,
Anne A. Knowlton,
Peter J. Havel,
Heinrich Taegtmeyer,
Donald M. Bers,
Florin Despa
Publication year - 2012
Publication title -
circulation research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 4.899
H-Index - 336
eISSN - 1524-4571
pISSN - 0009-7330
DOI - 10.1161/circresaha.111.258285
Subject(s) - amylin , medicine , endocrinology , diabetic cardiomyopathy , hyperinsulinemia , insulin resistance , myocyte , diabetes mellitus , type 2 diabetes , heart failure , cardiac myocyte , cardiomyopathy , islet
Hyperamylinemia is common in patients with obesity and insulin resistance, coincides with hyperinsulinemia, and results in amyloid deposition. Amylin amyloids are generally considered a pancreatic disorder in type 2 diabetes. However, elevated circulating levels of amylin may also lead to amylin accumulation and proteotoxicity in peripheral organs, including the heart.
Accelerating Research
Robert Robinson Avenue,
Oxford Science Park, Oxford
OX4 4GP, United Kingdom
Address
John Eccles HouseRobert Robinson Avenue,
Oxford Science Park, Oxford
OX4 4GP, United Kingdom