MicroRNA-23 Restricts Cardiac Valve Formation by Inhibiting Has2 and Extracellular Hyaluronic Acid Production | Zendy

Anne K. Lagendijk | Zendy; MarieJosé Goumans | Zendy; Silja Burkhard | Zendy; Jeroen Bakkers | Zendy

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MicroRNA-23 Restricts Cardiac Valve Formation by Inhibiting Has2 and Extracellular Hyaluronic Acid Production

Author(s) -

Anne K. Lagendijk,

MarieJosé Goumans,

Silja Burkhard,

Jeroen Bakkers

Publication year - 2011

Publication title -

circulation research

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 4.899

H-Index - 336

eISSN - 1524-4571

pISSN - 0009-7330

DOI - 10.1161/circresaha.111.247635

Subject(s) - hyaluronic acid , microbiology and biotechnology , downregulation and upregulation , extracellular matrix , endocardium , dicer , microrna , zebrafish , biology , heart development , angiogenesis , embryonic stem cell , chemistry , cancer research , biochemistry , anatomy , medicine , small interfering rna , transfection , gene

Since their discovery almost 20 years ago, microRNAs have been shown to perform essential roles during tissue development and disease. Although roles for microRNAs in the myocardium during embryo development and cardiac disease have been demonstrated, very little is know about their role in the endocardium or during cardiac valve formation.

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