Interleukin-17–Dependent Autoimmunity to Collagen Type V in Atherosclerosis | Zendy

Melanie L. Dart | Zendy; Ewa Jankowska−Gan | Zendy; Guorui Huang | Zendy; Drew A. Roenneburg | Zendy; Melissa R. Keller | Zendy; José Torrealba | Zendy; Aaron Rhoads | Zendy; Byoungjae Kim | Zendy; Joseph L. Bobadilla | Zendy; Lynn D. Haynes | Zendy; David S. Wilkes | Zendy; William J. Burlingham | Zendy; Daniel S. Greenspan | Zendy

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Interleukin-17–Dependent Autoimmunity to Collagen Type V in Atherosclerosis

Author(s) -

Melanie L. Dart,

Ewa Jankowska−Gan,

Guorui Huang,

Drew A. Roenneburg,

Melissa R. Keller,

José Torrealba,

Aaron Rhoads,

Byoungjae Kim,

Joseph L. Bobadilla,

Lynn D. Haynes,

David S. Wilkes,

William J. Burlingham,

Daniel S. Greenspan

Publication year - 2010

Publication title -

circulation research

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 4.899

H-Index - 336

eISSN - 1524-4571

pISSN - 0009-7330

DOI - 10.1161/circresaha.110.221069

Subject(s) - autoimmunity , pathogenesis , immunology , apolipoprotein e , immunity , inflammation , immune system , medicine , biology , disease , pathology

Considerable evidence shows atherosclerosis to be a chronic inflammatory disease in which immunity to self-antigens contributes to disease progression. We recently identified the collagen type V [col(V)] α1(V) chain as a key autoantigen driving the Th17-dependent cellular immunity underlying another chronic inflammatory disease, obliterative bronchiolitis. Because specific induction of α1(V) chains has previously been reported in human atheromas, we postulated involvement of col(V) autoimmunity in atherosclerosis.

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