Short Communication: Oxidative Posttranslational Modifications Mediate Decreased SERCA Activity and Myocyte Dysfunction in Gαq-Overexpressing Mice | Zendy

Steve Lancel | Zendy; Fuzhong Qin | Zendy; Shan L. Len | Zendy; Jingmei Zhang | Zendy; Xiaoyong Tong | Zendy; Michael J. Mazzini | Zendy; Y. James Kang | Zendy; Deborah A. Siwik | Zendy; Richard A. Cohen | Zendy; Wilson S. Colucci | Zendy

Open Access

Short Communication: Oxidative Posttranslational Modifications Mediate Decreased SERCA Activity and Myocyte Dysfunction in Gαq-Overexpressing Mice

Author(s) -

Steve Lancel,

Fuzhong Qin,

Shan L. Len,

Jingmei Zhang,

Xiaoyong Tong,

Michael J. Mazzini,

Y. James Kang,

Deborah A. Siwik,

Richard A. Cohen,

Wilson S. Colucci

Publication year - 2010

Publication title -

circulation research

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 4.899

H-Index - 336

eISSN - 1524-4571

pISSN - 0009-7330

DOI - 10.1161/circresaha.110.217570

Subject(s) - myocyte , oxidative phosphorylation , microbiology and biotechnology , serca , oxidative stress , posttranslational modification , chemistry , cardiac myocyte , medicine , biology , endocrinology , biochemistry , enzyme , atpase

Myocyte contractile dysfunction occurs in pathological remodeling in association with abnormalities in calcium regulation. Mice with cardiac myocyte-specific overexpression of Galphaq develop progressive left ventricular failure associated with myocyte contractile dysfunction and calcium dysregulation.

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