Open AccessIntegrin Cytoplasmic Domain–Associated Protein-1 Attenuates Sprouting Angiogenesis
Author(s) -
René Brütsch,
Sven S. Liebler,
Joycelyn Wüstehube,
Arne Bartol,
Stefanie E. Herberich,
Mohamed Adam,
Anja Telzerow,
Hellmut G. Augustin,
Andreas Fischer
Publication year - 2010
Publication title -
circulation research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 4.899
H-Index - 336
eISSN - 1524-4571
pISSN - 0009-7330
DOI - 10.1161/circresaha.110.217257
Subject(s) - angiogenesis , integrin , sprouting , microbiology and biotechnology , sprouting angiogenesis , cytoplasm , neovascularization , chemistry , biology , cancer research , biochemistry , cell , botany
The ICAP1 (integrin cytoplasmic domain-associated protein-1) is a specific intracellular binding protein of beta1-integrins and the cerebral cavernous malformation (CCM) protein CCM1. ICAP1 recruits CCM1 to the cell membrane and activates CCM1 by changing its conformation. Because CCM1 plays a critical role for cardiovascular development, we hypothesized that its activator ICAP1 is involved in vascular differentiation.
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