Open AccessRelative Roles of Direct Regeneration Versus Paracrine Effects of Human Cardiosphere-Derived Cells Transplanted Into Infarcted Mice
Author(s) -
Isotta Chimenti,
Rachel Smith,
TaoSheng Li,
Gary Gerstenblith,
Elisa Messina,
Alessandro Giacomello,
Eduardo Marbán
Publication year - 2010
Publication title -
circulation research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 4.899
H-Index - 336
eISSN - 1524-4571
pISSN - 0009-7330
DOI - 10.1161/circresaha.109.210682
Subject(s) - paracrine signalling , regeneration (biology) , microbiology and biotechnology , transplantation , biology , progenitor cell , umbilical vein , stem cell , growth factor , hepatocyte growth factor , vascular endothelial growth factor , myocyte , cell therapy , cancer research , immunology , medicine , in vitro , receptor , vegf receptors , biochemistry
Multiple biological mechanisms contribute to the efficacy of cardiac cell therapy. Most prominent among these are direct heart muscle and blood vessel regeneration from transplanted cells, as opposed to paracrine enhancement of tissue preservation and/or recruitment of endogenous repair.
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