Short Communication: The Neuropeptide Substance P Mediates Adventitial Mast Cell Activation and Induces Intraplaque Hemorrhage in Advanced Atherosclerosis | Zendy

Ilze Bot | Zendy; Saskia C.A. de Jager | Zendy; Martine Bot | Zendy; Sandra H. van Heiningen | Zendy; Paul de Groot | Zendy; Roel W. Veldhuizen | Zendy; Theo J.C. van Berkel | Zendy; Jan H. von der Thüsen | Zendy; Erik A.L. Biessen | Zendy

Open Access

Short Communication: The Neuropeptide Substance P Mediates Adventitial Mast Cell Activation and Induces Intraplaque Hemorrhage in Advanced Atherosclerosis

Author(s) -

Ilze Bot,

Saskia C.A. de Jager,

Martine Bot,

Sandra H. van Heiningen,

Paul de Groot,

Roel W. Veldhuizen,

Theo J.C. van Berkel,

Jan H. von der Thüsen,

Erik A.L. Biessen

Publication year - 2009

Publication title -

circulation research

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 4.899

H-Index - 336

eISSN - 1524-4571

pISSN - 0009-7330

DOI - 10.1161/circresaha.109.204875

Subject(s) - substance p , mast cell , adventitia , inflammation , neuropeptide , histamine , medicine , neuropeptide y receptor , receptor , pathology , endocrinology , immunology

Although we and others have recently shown that mast cells play an important role in plaque progression and destabilization, the nature of the actual trigger for (peri)vascular mast cell activation during atherosclerosis is still unresolved.

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