Open AccessInduction of Transglutaminase 2 by a Liver X Receptor/Retinoic Acid Receptor α Pathway Increases the Clearance of Apoptotic Cells by Human Macrophages
Author(s) -
Cédric Rébé,
Magalie Raveneau,
Angélique Chevriaux,
Daniela Lakomy,
Anne-Laure Sberna,
Annie Costa,
Ginette Bessède,
Anne Athias,
Éric Steinmetz,
Jean Marc Lobaccaro,
Georges Alves,
Alexandre Menicacci,
Sébastien Vachenc,
Éric Solary,
Philippe Gambert,
David Masson
Publication year - 2009
Publication title -
circulation research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 4.899
H-Index - 336
eISSN - 1524-4571
pISSN - 0009-7330
DOI - 10.1161/circresaha.109.201855
Subject(s) - tissue transglutaminase , apoptosis , retinoic acid , receptor , retinoic acid receptor , microbiology and biotechnology , signal transduction , cancer research , chemistry , biology , biochemistry , enzyme , gene
Liver X receptors (LXRs) are oxysterol-activated nuclear receptors that are involved in the control of cholesterol homeostasis and inflammatory response. Human monocytes and macrophages express high levels of these receptors and are appropriate cells to study the response to LXR agonists.
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