Role of Mesodermal FGF8 and FGF10 Overlaps in the Development of the Arterial Pole of the Heart and Pharyngeal Arch Arteries | Zendy

Yusuke Watanabe | Zendy; Sachiko MiyagawaTomita | Zendy; Stéphane D. Vincent | Zendy; Robert G. Kelly | Zendy; Anne Moon | Zendy; Margaret Buckingham | Zendy

Open Access

Role of Mesodermal FGF8 and FGF10 Overlaps in the Development of the Arterial Pole of the Heart and Pharyngeal Arch Arteries

Author(s) -

Yusuke Watanabe,

Sachiko MiyagawaTomita,

Stéphane D. Vincent,

Robert G. Kelly,

Anne Moon,

Margaret Buckingham

Publication year - 2009

Publication title -

circulation research

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 4.899

H-Index - 336

eISSN - 1524-4571

pISSN - 0009-7330

DOI - 10.1161/circresaha.109.201665

Subject(s) - fgf8 , fgf10 , mesoderm , heart development , biology , fgf and mesoderm formation , fibroblast growth factor , anatomy , ectoderm , population , medicine , embryogenesis , embryo , microbiology and biotechnology , genetics , embryonic stem cell , gene , receptor , environmental health

The genes encoding fibroblast growth factor (FGF) 8 and 10 are expressed in the anterior part of the second heart field that constitutes a population of cardiac progenitor cells contributing to the arterial pole of the heart. Previous studies of hypomorphic and conditional Fgf8 mutants show disrupted outflow tract (OFT) and right ventricle (RV) development, whereas Fgf10 mutants do not have detectable OFT defects.

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