Aldose Reductase Protects Against Early Atherosclerotic Lesion Formation in Apolipoprotein E-Null Mice | Zendy

Sanjay Srivastava | Zendy; Elena Vladykovskaya | Zendy; Oleg A. Barski | Zendy; Matthew Spite | Zendy; Karin Kaiserová | Zendy; J. Mark Petrash | Zendy; Stephen S.M. Chung | Zendy; Greg Hunt | Zendy; Buddhadeb Dawn | Zendy; Aruni Bhatnagar | Zendy

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Aldose Reductase Protects Against Early Atherosclerotic Lesion Formation in Apolipoprotein E-Null Mice

Author(s) -

Sanjay Srivastava,

Elena Vladykovskaya,

Oleg A. Barski,

Matthew Spite,

Karin Kaiserová,

J. Mark Petrash,

Stephen S.M. Chung,

Greg Hunt,

Buddhadeb Dawn,

Aruni Bhatnagar

Publication year - 2009

Publication title -

circulation research

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 4.899

H-Index - 336

eISSN - 1524-4571

pISSN - 0009-7330

DOI - 10.1161/circresaha.109.200568

Subject(s) - lesion , aldose reductase , apolipoprotein e , sorbinil , apolipoprotein b , endocrinology , medicine , biology , chemistry , pathology , cholesterol , diabetes mellitus , aldose reductase inhibitor , disease

Atherosclerotic lesion formation is associated with the accumulation of oxidized lipids. Products of lipid oxidation, particularly aldehydes, stimulate cytokine production and enhance monocyte adhesion; however, their contribution to atherosclerotic lesion formation remains unclear.

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