Open AccessFunctional Characterization of a Putative Serine Carboxypeptidase in Vascular Smooth Muscle Cells
Author(s) -
Ting-Hein Lee,
Jiyuan Chen,
Joseph M. Miano
Publication year - 2009
Publication title -
circulation research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 4.899
H-Index - 336
eISSN - 1524-4571
pISSN - 0009-7330
DOI - 10.1161/circresaha.109.199869
Subject(s) - neointima , vascular smooth muscle , microbiology and biotechnology , gene knockdown , cell growth , biology , serine , cell migration , knockout mouse , small hairpin rna , cell , receptor , cell culture , biochemistry , endocrinology , medicine , phosphorylation , genetics , restenosis , smooth muscle , stent
We previously identified a novel serine carboxypeptidase, SCPEP1, that undergoes cleavage across all tissues where it is expressed. SCPEP1 bears the signature catalytic triad found in all serine carboxypeptidases, but its biological function is completely unknown.
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