Impact of Fluoropolymer-Based Paclitaxel Delivery on Neointimal Proliferation and Vascular Healing | Zendy

Paweł Gąsior | Zendy; Yanping Cheng | Zendy; Andres Valencia | Zendy; Jenn McGregor | Zendy; Gerard Conditt | Zendy; Grzegorz L. Kałuża | Zendy; Juan F. Granada | Zendy

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Impact of Fluoropolymer-Based Paclitaxel Delivery on Neointimal Proliferation and Vascular Healing

Author(s) -

Paweł Gąsior,

Yanping Cheng,

Andres Valencia,

Jenn McGregor,

Gerard Conditt,

Grzegorz L. Kałuża,

Juan F. Granada

Publication year - 2017

Publication title -

circulation cardiovascular interventions

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.621

H-Index - 95

eISSN - 1941-7632

pISSN - 1941-7640

DOI - 10.1161/circinterventions.116.004450

Subject(s) - medicine , restenosis , fluoropolymer , stent , angioplasty , paclitaxel , lumen (anatomy) , drug eluting stent , optical coherence tomography , urology , radiology , surgery , chemotherapy , polymer , chemistry , organic chemistry

A polymer-free peripheral paclitaxel-eluting stent (PES, Zilver PTX, Cook, IN) has shown to improve vessel patency after superficial femoral angioplasty. A new-generation fluoropolymer-based PES (FP-PES; Eluvia, Boston Scientific, MA) displaying more controlled and sustained paclitaxel delivery promise to improve the clinical outcomes of first-generation PES. We sought to compare the biological effect of paclitaxel delivered by 2 different stent-coating technologies (fluoropolymer-based versus polymer-free) on neointimal proliferation and healing response in the familial hypercholesterolemic swine model of femoral restenosis.

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