Intracoronary Delivery of Self-Assembling Heart-Derived Microtissues (Cardiospheres) for Prevention of Adverse Remodeling in a Pig Model of Convalescent Myocardial Infarction | Zendy

Romain Gallet | Zendy; Eleni Tseliou | Zendy; James Dawkins | Zendy; Ryan Middleton | Zendy; Jackelyn Valle | Zendy; David Angert | Zendy; Heidi Reich | Zendy; Daniel Luthringer | Zendy; Michelle Kreke | Zendy; Rachel Smith | Zendy; Linda Marbán | Zendy; Eduardo Marbán | Zendy

Open Access

Intracoronary Delivery of Self-Assembling Heart-Derived Microtissues (Cardiospheres) for Prevention of Adverse Remodeling in a Pig Model of Convalescent Myocardial Infarction

Author(s) -

Romain Gallet,

Eleni Tseliou,

James Dawkins,

Ryan Middleton,

Jackelyn Valle,

David Angert,

Heidi Reich,

Daniel Luthringer,

Michelle Kreke,

Rachel Smith,

Linda Marbán,

Eduardo Marbán

Publication year - 2015

Publication title -

circulation cardiovascular interventions

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.621

H-Index - 95

eISSN - 1941-7632

pISSN - 1941-7640

DOI - 10.1161/circinterventions.115.002391

Subject(s) - medicine , myocardial infarction , cardiology , ejection fraction , adverse effect , ventricular remodeling , perfusion , infarction , artery , heart failure

Preclinical studies in rodents and pigs indicate that the self-assembling microtissues known as cardiospheres may be more effective than dispersed cardiosphere-derived cells. However, the more desirable intracoronary route has been assumed to be unsafe for cardiosphere delivery: Cardiospheres are large (30-150 μm), raising concerns about likely microembolization. We questioned these negative assumptions by evaluating the safety and efficacy of optimized intracoronary delivery of cardiospheres in a porcine model of convalescent myocardial infarction.

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