Proton Pump Inhibitors, Platelet Reactivity, and Cardiovascular Outcomes After Drug-Eluting Stents in Clopidogrel-Treated Patients | Zendy

Giora Weisz | Zendy; Nathaniel R. Smilowitz | Zendy; Ajay J. Kirtane | Zendy; Michael J. Rinaldi | Zendy; Rupa Parvataneni | Zendy; Ke Xu | Zendy; Thomas Stuckey | Zendy; Akiko Maehara | Zendy; Bernhard Witzenbichler | Zendy; FranzJosef Neumann | Zendy; D. Christopher Metzger | Zendy; Timothy D. Henry | Zendy; David A. Cox | Zendy; Peter L. Duffy | Zendy; Bruce R. Brodie | Zendy; Ernest L. Mazzaferri | Zendy; Roxana Mehran | Zendy; Gregg W. Stone | Zendy

Open Access

Proton Pump Inhibitors, Platelet Reactivity, and Cardiovascular Outcomes After Drug-Eluting Stents in Clopidogrel-Treated Patients

Author(s) -

Giora Weisz,

Nathaniel R. Smilowitz,

Ajay J. Kirtane,

Michael J. Rinaldi,

Rupa Parvataneni,

Ke Xu,

Thomas Stuckey,

Akiko Maehara,

Bernhard Witzenbichler,

FranzJosef Neumann,

D. Christopher Metzger,

Timothy D. Henry,

David A. Cox,

Peter L. Duffy,

Bruce R. Brodie,

Ernest L. Mazzaferri,

Roxana Mehran,

Gregg W. Stone

Publication year - 2015

Publication title -

circulation cardiovascular interventions

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.621

H-Index - 95

eISSN - 1941-7632

pISSN - 1941-7640

DOI - 10.1161/circinterventions.114.001952

Subject(s) - clopidogrel , medicine , p2y12 , cardiology , odds ratio , concomitant , hazard ratio , drug eluting stent , myocardial infarction , percutaneous coronary intervention , confidence interval

Certain proton pump inhibitors (PPIs) interfere with clopidogrel metabolism, potentially attenuating P2Y12 receptor inhibition. Previous observational and randomized trials report conflicting results regarding the clinical significance of this pharmacological interaction. We examined the interaction between concomitant administration of PPI and clopidogrel on platelet reactivity and clinical outcomes in the large-scale, prospective Assessment of Dual AntiPlatelet Therapy With Drug-Eluting Stents study.

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