Incomplete Stent Apposition Causes High Shear Flow Disturbances and Delay in Neointimal Coverage as a Function of Strut to Wall Detachment Distance | Zendy

Nicolas Foin | Zendy; Juan Luis GutiérrezChico | Zendy; Shimpei Nakatani | Zendy; Ryo Torii | Zendy; Christos V. Bourantas | Zendy; Sayan Sen | Zendy; Sukhjinder Nijjer | Zendy; Ricardo Petraco | Zendy; Chrysa A. Kousera | Zendy; Matteo Ghione | Zendy; Yoshinobu Onuma | Zendy; Héctor M. GarcíaGarcía | Zendy; Dárrel P. Francis | Zendy; Philip Wong | Zendy; Carlo Di Mario | Zendy; Justin E. Davies | Zendy; Patrick W. Serruys | Zendy

Open Access

Incomplete Stent Apposition Causes High Shear Flow Disturbances and Delay in Neointimal Coverage as a Function of Strut to Wall Detachment Distance

Author(s) -

Nicolas Foin,

Juan Luis GutiérrezChico,

Shimpei Nakatani,

Ryo Torii,

Christos V. Bourantas,

Sayan Sen,

Sukhjinder Nijjer,

Ricardo Petraco,

Chrysa A. Kousera,

Matteo Ghione,

Yoshinobu Onuma,

Héctor M. GarcíaGarcía,

Dárrel P. Francis,

Philip Wong,

Carlo Di Mario,

Justin E. Davies,

Patrick W. Serruys

Publication year - 2014

Publication title -

circulation cardiovascular interventions

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.621

H-Index - 95

eISSN - 1941-7632

pISSN - 1941-7640

DOI - 10.1161/circinterventions.113.000931

Subject(s) - apposition , flow (mathematics) , function (biology) , stent , mechanics , shear (geology) , materials science , medicine , anatomy , physics , composite material , biology , microbiology and biotechnology

Lack of re-endothelialization and neointimal coverage on stent struts has been put forward as the main underlying mechanism leading to late stent thrombosis. Incomplete stent apposition (ISA) has been observed frequently in patients with very late stent thrombosis after drug eluting stent implantation, suggesting a role of ISA in the pathogenesis of this adverse event. The aim of this study was to evaluate the impact of different degrees of ISA severity on abnormal shear rate and healing response with coverage, because of its potential implications for stent optimization in clinical practice.

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