Letter by Sen et al Regarding Article, “Diagnostic Accuracy of Combined Intracoronary Pressure and Flow Velocity Information During Baseline Conditions: Adenosine-Free Assessment of Functional Coronary Lesion Severity”

We read with great interest the study by van de Hoef et al1 demonstrating the ability of the hyperemia-free Basal Stenosis Resistance index to detect ischemia.This is the second study in recent months to report that the hemodynamic significance of a coronary stenosis can be assessed without the administration of potent vasodilators.2 We believe that this is a highly significant observation, which may lead to a paradigm shift reversing the a priori …