Pharmacodynamic Effect of Switching Therapy in Patients With High On-Treatment Platelet Reactivity and Genotype Variation With High Clopidogrel Dose Versus Prasugrel | Zendy

Gennaro Sardella | Zendy; Simone Calcagno | Zendy; Massimo Mancone | Zendy; Raffaele Palmirotta | Zendy; Luigi Lucisano | Zendy; Emanuele Canali | Zendy; Rocco Edoardo Stio | Zendy; Mauro Pennacchi | Zendy; Angelo Di Roma | Zendy; Giulia Benedetti | Zendy; Fiorella Guadagni | Zendy; Giuseppe BiondiZoccai | Zendy; Francesco Fedele | Zendy

Open Access

Pharmacodynamic Effect of Switching Therapy in Patients With High On-Treatment Platelet Reactivity and Genotype Variation With High Clopidogrel Dose Versus Prasugrel

Author(s) -

Gennaro Sardella,

Simone Calcagno,

Massimo Mancone,

Raffaele Palmirotta,

Luigi Lucisano,

Emanuele Canali,

Rocco Edoardo Stio,

Mauro Pennacchi,

Angelo Di Roma,

Giulia Benedetti,

Fiorella Guadagni,

Giuseppe BiondiZoccai,

Francesco Fedele

Publication year - 2012

Publication title -

circulation cardiovascular interventions

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.621

H-Index - 95

eISSN - 1941-7632

pISSN - 1941-7640

DOI - 10.1161/circinterventions.112.972463

Subject(s) - prasugrel , clopidogrel , p2y12 , medicine , thienopyridine , cyp2c19 , percutaneous coronary intervention , pharmacology , aspirin , myocardial infarction , cytochrome p450 , metabolism

High on-treatment platelet reactivity (HTPR) is associated with adverse outcomes. We aim to compare the novel thienopyridine prasugrel versus double-dose clopidogrel in patients with HTPR and explore the interaction between CYP2C19 genotype and both drugs.

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