Effects of Endothelial Dysfunction on Residual Platelet Aggregability After Dual Antiplatelet Therapy With Aspirin and Clopidogrel in Patients With Stable Coronary Artery Disease | Zendy

Koichiro Fujisue | Zendy; Seigo Sugiyama | Zendy; Takamichi Ono | Zendy; Yasushi Matsuzawa | Zendy; Eiichi Akiyama | Zendy; Koichi Sugamura | Zendy; Junichi Matsubara | Zendy; Hirofumi Kurokawa | Zendy; Koichi Kaikita | Zendy; Satomi Iwashita | Zendy; Hitoshi Sumida | Zendy; Seiji Hokimoto | Zendy; Kentaro Oniki | Zendy; Kazuko Nakagawa | Zendy; Kunihiko Matsui | Zendy; Hisao Ogawa | Zendy

Open Access

Effects of Endothelial Dysfunction on Residual Platelet Aggregability After Dual Antiplatelet Therapy With Aspirin and Clopidogrel in Patients With Stable Coronary Artery Disease

Author(s) -

Koichiro Fujisue,

Seigo Sugiyama,

Takamichi Ono,

Yasushi Matsuzawa,

Eiichi Akiyama,

Koichi Sugamura,

Junichi Matsubara,

Hirofumi Kurokawa,

Koichi Kaikita,

Satomi Iwashita,

Hitoshi Sumida,

Seiji Hokimoto,

Kentaro Oniki,

Kazuko Nakagawa,

Kunihiko Matsui,

Hisao Ogawa

Publication year - 2013

Publication title -

circulation cardiovascular interventions

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.621

H-Index - 95

eISSN - 1941-7632

pISSN - 1941-7640

DOI - 10.1161/circinterventions.112.000278

Subject(s) - medicine , reactive hyperemia , clopidogrel , aspirin , p2y12 , cardiology , coronary artery disease , endothelial dysfunction , platelet activation , platelet , cyp2c19 , blood flow , cytochrome p450 , metabolism

Dual antiplatelet therapy with aspirin and clopidogrel is widely used in patients with coronary stents. High residual platelet reactivity (high RPR) after dual antiplatelet therapy is associated with increased cardiovascular events. Endothelial function could affect platelet reactivity in vivo. We hypothesized that endothelial dysfunction could be associated with high RPR after dual antiplatelet therapy in patients with stable coronary artery disease.

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