Effect of CYP2C19*2 and *3 Loss-of-Function Alleles on Platelet Reactivity and Adverse Clinical Events in East Asian Acute Myocardial Infarction Survivors Treated With Clopidogrel and Aspirin | Zendy

YoungHoon Jeong | Zendy; Udaya S. Tantry | Zendy; InSuk Kim | Zendy; Jin-Sin Koh | Zendy; Tae Jung Kwon | Zendy; Yongwhi Park | Zendy; Seok-Jae Hwang | Zendy; Kevin P. Bliden | Zendy; Choong Hwan Kwak | Zendy; JinYong Hwang | Zendy; Paul A. Gurbel | Zendy

Open Access

Effect of CYP2C19*2 and *3 Loss-of-Function Alleles on Platelet Reactivity and Adverse Clinical Events in East Asian Acute Myocardial Infarction Survivors Treated With Clopidogrel and Aspirin

Author(s) -

YoungHoon Jeong,

Udaya S. Tantry,

InSuk Kim,

Jin-Sin Koh,

Tae Jung Kwon,

Yongwhi Park,

Seok-Jae Hwang,

Kevin P. Bliden,

Choong Hwan Kwak,

JinYong Hwang,

Paul A. Gurbel

Publication year - 2011

Publication title -

circulation cardiovascular interventions

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.621

H-Index - 95

eISSN - 1941-7632

pISSN - 1941-7640

DOI - 10.1161/circinterventions.111.962555

Subject(s) - medicine , clopidogrel , myocardial infarction , cyp2c19 , adverse effect , cardiology , platelet , acute coronary syndrome , p2y12 , cytochrome p450 , metabolism

As compared with whites, East Asians more often carry the cytochrome P450 (CYP) 2C19 loss-of-function (LOF) allele with the CYP2C19*3 variant. The influence of the CYP2C19 LOF alleles (*2 and *3) on clopidogrel response and clinical outcomes in East Asians with acute myocardial infarction (AMI) has not been reported. We sought to evaluate the effect of the CYP2C19 variants on clopidogrel pharmacodynamics and long-term prognosis in these patients.

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