Vascular Responses to Drug-Eluting and Bare Metal Stents in Diabetic/Hypercholesterolemic and Nonatherosclerotic Porcine Coronary Arteries | Zendy

Raúl Llano | Zendy; Dawn Winsor-Hines | Zendy; Dhavalkumar Patel | Zendy; Paul S. Seifert | Zendy; Damir Hamamdzic | Zendy; Gregory J. Wilson | Zendy; Hong Wang | Zendy; Martin Keane | Zendy; Barbara Huibregtse | Zendy; Robert L. Wilensky | Zendy

Open Access

Vascular Responses to Drug-Eluting and Bare Metal Stents in Diabetic/Hypercholesterolemic and Nonatherosclerotic Porcine Coronary Arteries

Author(s) -

Raúl Llano,

Dawn Winsor-Hines,

Dhavalkumar Patel,

Paul S. Seifert,

Damir Hamamdzic,

Gregory J. Wilson,

Hong Wang,

Martin Keane,

Barbara Huibregtse,

Robert L. Wilensky

Publication year - 2011

Publication title -

circulation cardiovascular interventions

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.621

H-Index - 95

eISSN - 1941-7632

pISSN - 1941-7640

DOI - 10.1161/circinterventions.110.959957

Subject(s) - medicine , cardiology , coronary arteries , stent , diabetes mellitus , paclitaxel , drug eluting stent , bare metal stent , artery , coronary artery disease , urology , restenosis , endocrinology , chemotherapy

Animal models used to gain insight into the vascular response to drug-eluting stents are generally juvenile and nonatherosclerotic, whereas stents are placed in patients with complex atherosclerosis and comorbidities. Hence, models reflecting these complexities are needed to help elucidate the vascular effects of drug-eluting stents. We compared the vascular responses with bare metal stent (BMS) and paclitaxel-eluting stent (PES) implantation in a diabetic/hypercholesterolemic (DM/HC) porcine model of advanced coronary atherosclerosis with the standard juvenile porcine model.

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