A Pilot Study of Rapid Cooling by Cold Saline and Endovascular Cooling Before Reperfusion in Patients With ST-Elevation Myocardial Infarction | Zendy

Matthias Götberg | Zendy; Göran Olivecrona | Zendy; Sasha Koul | Zendy; Marcus Carlsson | Zendy; Henrik Engblom | Zendy; Martin Ugander | Zendy; Jesper van der Pals | Zendy; Lars Algotsson | Zendy; Håkan Arheden | Zendy; David Erlinge | Zendy

Open Access

A Pilot Study of Rapid Cooling by Cold Saline and Endovascular Cooling Before Reperfusion in Patients With ST-Elevation Myocardial Infarction

Author(s) -

Matthias Götberg,

Göran Olivecrona,

Sasha Koul,

Marcus Carlsson,

Henrik Engblom,

Martin Ugander,

Jesper van der Pals,

Lars Algotsson,

Håkan Arheden,

David Erlinge

Publication year - 2010

Publication title -

circulation cardiovascular interventions

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.621

H-Index - 95

eISSN - 1941-7632

pISSN - 1941-7640

DOI - 10.1161/circinterventions.110.957902

Subject(s) - medicine , hypothermia , myocardial infarction , percutaneous coronary intervention , cardiology , coronary occlusion , reperfusion therapy , anesthesia , saline , troponin t , infarction , ischemia

Experimental studies have shown that induction of hypothermia before reperfusion of acute coronary occlusion reduces infarct size. Previous clinical studies, however, have not been able to show this effect, which is believed to be mainly because therapeutic temperature was not reached before reperfusion in the majority of the patients. We aimed to evaluate the safety and feasibility of rapidly induced hypothermia by infusion of cold saline and endovascular cooling catheter before reperfusion in patients with acute myocardial infarction.

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