Open AccessPharmacodynamic Effects of Concomitant Versus Staggered Clopidogrel and Omeprazole Intake
Author(s) -
José Luis Ferreiro,
Masafumi Ueno,
Davide Capodanno,
Bhaloo Desai,
Kodlipet Dharmashankar,
Andrew Darlington,
Ronald K. Charlton,
Theodore A. Bass,
Dominick J. Angiolillo
Publication year - 2010
Publication title -
circulation cardiovascular interventions
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.621
H-Index - 95
eISSN - 1941-7632
pISSN - 1941-7640
DOI - 10.1161/circinterventions.110.957829
Subject(s) - omeprazole , clopidogrel , pharmacodynamics , concomitant , medicine , pharmacology , pharmacokinetics , aspirin
A drug interaction between clopidogrel and omeprazole resulting in impaired platelet inhibition has been reported. It has been suggested that staggering administration of clopidogrel and omeprazole may overcome this pharmacodynamic (PD) interaction.
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