Strut Coverage and Vessel Wall Response to a New-Generation Paclitaxel-Eluting Stent With an Ultrathin Biodegradable Abluminal Polymer | Zendy

Giulio Guagliumi | Zendy; Vasile Sirbu | Zendy; Giuseppe Musumeci | Zendy; Hiram G. Bezerra | Zendy; Alessandro Aprile | Zendy; Hiroyuki Kyono | Zendy; Luigi Fiocca | Zendy; Aleksandre Matiashvili | Zendy; Nikoloz Lortkipanidze | Zendy; Angelina Vassileva | Zendy; Jeffrey J. Popma | Zendy; Dominic J. Allocco | Zendy; Keith D. Dawkins | Zendy; Orazio Valsecchi | Zendy; Marco A. Costa | Zendy

Open Access

Strut Coverage and Vessel Wall Response to a New-Generation Paclitaxel-Eluting Stent With an Ultrathin Biodegradable Abluminal Polymer

Author(s) -

Giulio Guagliumi,

Vasile Sirbu,

Giuseppe Musumeci,

Hiram G. Bezerra,

Alessandro Aprile,

Hiroyuki Kyono,

Luigi Fiocca,

Aleksandre Matiashvili,

Nikoloz Lortkipanidze,

Angelina Vassileva,

Jeffrey J. Popma,

Dominic J. Allocco,

Keith D. Dawkins,

Orazio Valsecchi,

Marco A. Costa

Publication year - 2010

Publication title -

circulation cardiovascular interventions

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.621

H-Index - 95

eISSN - 1941-7632

pISSN - 1941-7640

DOI - 10.1161/circinterventions.110.950154

Subject(s) - restenosis , stent , paclitaxel , neointimal hyperplasia , optical coherence tomography , medicine , thrombus , drug eluting stent , nuclear medicine , biomedical engineering , radiology , surgery , chemotherapy

Polymer-coated drug-eluting stents are effective in preventing restenosis but have been associated with delayed healing and incomplete strut coverage. It is unknown whether paclitaxel-eluting stents (PES) with minimal biodegradable abluminal coating enhances strut coverage while preventing neointimal hyperplasia. Using optical coherence tomography (OCT) as a primary imaging modality, we assessed the proportion of uncovered struts at 6-month follow-up in PES coated with durable versus ultrathin (<1 microm) biodegradable abluminal polymers.

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