Impact of a Single Intracoronary Administration of Adiponectin on Myocardial Ischemia/Reperfusion Injury in a Pig Model | Zendy

Kazuhisa Kondo | Zendy; Rei Shibata | Zendy; Kazumasa Unno | Zendy; Masayuki Shimano | Zendy; Masakazu Ishii | Zendy; Tetsutaro Kito | Zendy; Satoshi Shintani | Zendy; Kenneth Walsh | Zendy; Noriyuki Ouchi | Zendy; Toyoaki Murohara | Zendy

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Impact of a Single Intracoronary Administration of Adiponectin on Myocardial Ischemia/Reperfusion Injury in a Pig Model

Author(s) -

Kazuhisa Kondo,

Rei Shibata,

Kazumasa Unno,

Masayuki Shimano,

Masakazu Ishii,

Tetsutaro Kito,

Satoshi Shintani,

Kenneth Walsh,

Noriyuki Ouchi,

Toyoaki Murohara

Publication year - 2010

Publication title -

circulation cardiovascular interventions

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.621

H-Index - 95

eISSN - 1941-7632

pISSN - 1941-7640

DOI - 10.1161/circinterventions.109.872044

Subject(s) - cardiology , adiponectin , medicine , reperfusion injury , myocardial ischemia , ischemia , insulin resistance , insulin

Adiponectin plays a protective role in the development of obesity-linked disorders. We demonstrated that adiponectin exerts beneficial actions on acute ischemic injury in mice hearts. However, the effects of adiponectin treatment in large animals and its feasibility in clinical practice have not been investigated. This study investigated the effects of intracoronary administration of adiponectin on myocardial ischemia-reperfusion (I/R) injury in pigs.

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