Impact of NAD(P)H Oxidase-Derived Reactive Oxygen Species on Coronary Arterial Remodeling | Zendy

Mitsuyasu Terashima | Zendy; Yoshitaka Ohashi | Zendy; Hiroshi Azumi | Zendy; Kazunori Otsui | Zendy; Hideaki Kaneda | Zendy; Kojiro Awano | Zendy; Seiichi Kobayashi | Zendy; Tomoyuki Honjo | Zendy; Takahiko Suzuki | Zendy; Kazumi Maeda | Zendy; Mitsuhiro Yokoyama | Zendy; Nobutaka Inoue | Zendy

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Impact of NAD(P)H Oxidase-Derived Reactive Oxygen Species on Coronary Arterial Remodeling

Author(s) -

Mitsuyasu Terashima,

Yoshitaka Ohashi,

Hiroshi Azumi,

Kazunori Otsui,

Hideaki Kaneda,

Kojiro Awano,

Seiichi Kobayashi,

Tomoyuki Honjo,

Takahiko Suzuki,

Kazumi Maeda,

Mitsuhiro Yokoyama,

Nobutaka Inoue

Publication year - 2009

Publication title -

circulation cardiovascular interventions

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.621

H-Index - 95

eISSN - 1941-7632

pISSN - 1941-7640

DOI - 10.1161/circinterventions.108.799502

Subject(s) - intravascular ultrasound , medicine , expansive , ventricular remodeling , coronary atherosclerosis , lesion , reactive oxygen species , cardiology , pathology , arterial stiffness , chemistry , coronary artery disease , myocardial infarction , biochemistry , blood pressure , materials science , compressive strength , composite material

Coronary arterial remodeling, which is a response to the growth of atherosclerotic plaques, is associated with plaque vulnerability. Oxidative stress induced by reactive oxygen species (ROS) via NAD(P)H oxidase in the vasculature also plays a crucial role in the pathogenesis of atherosclerosis-based cardiovascular disease. In this study, the relationship between coronary arterial remodeling and ROS generation was examined by comparing preinterventional intravascular ultrasound findings of atherosclerotic lesions to the histochemical findings of corresponding specimens obtained by directional coronary atherectomy.

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