Long-Term Outcome of Therapeutic Neovascularization Using Peripheral Blood Mononuclear Cells for Limb Ischemia | Zendy

Junji Moriya | Zendy; Tohru Minamino | Zendy; Kaoru Tateno | Zendy; Naomi Shimizu | Zendy; Yoichi Kuwabara | Zendy; Yasunori Sato | Zendy; Yasushi Saitō | Zendy; Issei Komuro | Zendy

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Long-Term Outcome of Therapeutic Neovascularization Using Peripheral Blood Mononuclear Cells for Limb Ischemia

Author(s) -

Junji Moriya,

Tohru Minamino,

Kaoru Tateno,

Naomi Shimizu,

Yoichi Kuwabara,

Yasunori Sato,

Yasushi Saitō,

Issei Komuro

Publication year - 2009

Publication title -

circulation cardiovascular interventions

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.621

H-Index - 95

eISSN - 1941-7632

pISSN - 1941-7640

DOI - 10.1161/circinterventions.108.799361

Subject(s) - peripheral blood mononuclear cell , medicine , ischemia , neovascularization , peripheral , term (time) , peripheral blood , cardiology , limb ischemia , angiogenesis , biology , biochemistry , in vitro , physics , quantum mechanics

Injection of bone marrow mononuclear cells has been reported to promote neovascularization of ischemic tissues effectively. We found that peripheral blood mononuclear cells were as efficient as bone marrow mononuclear cells for the treatment of limb ischemia in animals and showed that this treatment was feasible and safe in no-option patients with limb ischemia. However, the long-term outcome of such therapy has not been investigated.

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